Asian Journal of Research in Chemistry

V. Prabhakar ¹, K. Sudhakar Babu ¹, L. K. Ravindranath ¹, P. V. Ramana Reddy ², J. Latha ³

Affiliations
1 Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu, (A P), IN
2 Department of Chemistry, Loyola Degree College, Sri Yogivemana University, Kadapa , (A P), IN
3 Department of Bio-Technology, Sri Krishnadevaraya University College of Engineering and Technology, Anantapuramu – 515003 (A.P), IN

Abstract

A Novel Series of Compounds were synthesized by Condensation reaction of Carbazole aldehyde with Substituted Acetophenone derivatives 4 (a-d) in presence of alcoholic Sodium hydroxide Solution to get Chalcone Intermediates 5 (a-d), which were further treated hydroxyl amine hydrochloride in presence of Pyridine to get Iso Oxazoline Derivatives 6 (a-d). The latter were refluxed with Substituted Primary amines and formaldehyde for 8-10 hrs to get Mannich bases. The Structures of new compounds were confirmed by IR and 1H NMR and 13C NMR Spectral Data. Anti-bacterial and Anti-fungal Activities were evaluated and compared with the standard drugs, some compounds of the series Exhibited Promising Anti-microbial and Anti-fungal Activity Compared to Standard Drugs.

Keywords

Chalcone, Isoxazoline, Carbazoles, Mannich Bases, Anti-Bacterial, Antifungal Activity.

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V. Prabhakar ¹, C. Divya Vani ², G. Govindu ¹

Affiliations
1 Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, Andhra Pradesh, IN
2 Department of Chemistry, Sri Padmavati Women’s Degree and PG College, Tirupati, Andhra Pradesh, IN

Abstract

Heterocyclic compounds occur widely in nature and quite a few of these are essential to life processes. The literature on heterocyclic compounds is replete with examples of a large number of synthetic methods of naturally occurring systems which are pharmacologically active. The heterocyclic compounds containing nitrogen has expanded exponentially in the past decades due to their unique physical properties, specific chemical reactivity and their remarkable potential biological activities. A survey of literature on the nitrogen heterocyclic reveal that dia zepines are important constituents of a wide variety of natural products with pharmacodynamic application. The Structures of the Synthesized Compounds are Confirmed by IR, ¹H NMR and ¹³C NMR Spectral data, Elemental Analysis, Mass spectral data. The compounds are also evaluated for their anti Oxidant activity by DPPH method, among them 13e and 13d are found as potent activity. The reaction proceeds efficiently under ambient conditions with good-to-excellent yields.

Keywords

Benzo Diazepines, Synthesis, Anti Oxidant Activity, Biological Importance, DPPH.

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